Actovegin 200 mg Tablets (50 Tablets)
Actovegin 200 mg tablets are an oral dosage form containing a deproteinized hemoderivative
obtained from calf blood. The product is used in clinical practice to support cellular metabolism
and tissue trophism, particularly in conditions associated with impaired cerebral circulation.
This informational leaflet provides a structured overview of Actovegin 200 mg tablets,
including composition, mechanism of action, indications, dosage principles, precautions,
and safety-related information.
Pharmaceutical Form and Composition
Actovegin is supplied in the form of coated tablets (or dragees, depending on the market).
Each tablet contains:
- Active substance: Deproteinized hemoderivative from calf blood – 200 mg
- Excipients: Formulation-dependent auxiliary substances used for tablet stability,
coating, and bioavailability
The active substance is obtained through multistage filtration processes designed to remove
high-molecular proteins, resulting in a complex of low-molecular components.
Pharmacological Properties
Actovegin is classified as a metabolic agent. Its pharmacological profile is associated with
enhanced utilization of oxygen and glucose at the cellular level, which may support energy
production in tissues exposed to hypoxic or ischemic conditions.
The proposed effects include:
- Improved cellular energy metabolism
- Support of oxygen uptake in tissues
- Facilitation of glucose transport and utilization
- Support of tissue trophism under compromised circulation
Due to the biological origin of the active substance, the exact mechanism of action is considered
multifactorial and is described in clinical literature as a combined metabolic and antihypoxic effect.
Indications for Use
According to official product documentation, Actovegin 200 mg tablets are indicated for:
- Cerebral circulatory and trophic disorders
- Continuation of therapy following injectable or infusion treatment
in cerebral circulation disorders
The tablet form is typically used when oral administration is considered appropriate by a clinician,
including outpatient or follow-up treatment phases.
Dosage and Method of Administration
Dosage and duration of therapy are determined individually by a healthcare professional.
General principles described in product documentation include:
- Tablets are taken orally with water
- Administration is usually recommended before meals
- Typical dosing may involve 1–2 tablets per dose, depending on clinical judgement
The duration of treatment commonly extends over several weeks. Patients should follow
the prescribing physician’s instructions and should not alter the dosage independently.
Contraindications
Actovegin should not be used in patients with known hypersensitivity to the active substance
or any of the excipients contained in the tablet formulation.
Use of the product is contraindicated in individuals with a history of severe allergic reactions
to biological medicinal products.
Warnings and Precautions
Special caution is advised in the following situations:
- History of allergic reactions or atopic conditions
- Known intolerance to specific excipients (depending on formulation)
- Pregnancy or breastfeeding
Patients should inform their healthcare provider about all concomitant medications,
dietary supplements, and relevant medical conditions prior to initiating therapy.
Use During Pregnancy and Breastfeeding
Use of Actovegin during pregnancy or lactation should only occur under medical supervision.
The decision to prescribe the medication is based on an individual assessment of
potential benefits and risks.
Possible Side Effects
As with all medicinal products, Actovegin may cause adverse reactions, although not all
patients experience them.
- Allergic skin reactions (rash, itching, urticaria)
- Flushing or sensation of warmth
- Rarely, severe hypersensitivity reactions
If signs of an allergic reaction occur, the medication should be discontinued and medical
advice sought immediately.
Drug Interactions
Patients are advised to inform their healthcare provider about all medications they are taking.
No specific interaction patterns are highlighted in standard product documentation, but
medical supervision is recommended when combining therapies.
Storage Conditions
- Store at room temperature according to package instructions
- Protect from moisture and excessive heat
- Keep out of the reach of children
- Do not use after the stated expiration date
Clinical Use Considerations
In clinical practice, Actovegin 200 mg tablets are frequently used as part of a structured
treatment plan, particularly as oral continuation therapy following parenteral administration.
The choice of dosage form and duration of therapy depends on diagnosis, severity of symptoms,
patient response, and overall treatment strategy.
Summary
Actovegin 200 mg tablets represent an oral formulation of a metabolic medicinal product
used to support cerebral circulation and tissue trophism. The medication is administered
according to medical guidance and is typically incorporated into comprehensive treatment
regimens under professional supervision.