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Available Forms of Actovegin
- Injectable solution: 40 mg/mL (2 mL, 5 mL ampoules)
- Tablets: 200 mg
- Topicals: Ointment, cream, gel
General Indications
- Neurological disorders (ischemic stroke, head trauma, dementia)
- Peripheral vascular disease (trophic ulcers, angiopathy)
- Diabetic polyneuropathy
- Burns and radiation-induced skin/mucosal injury
- Wound care (cuts, ulcers, bedsores, skin grafts)
Contraindications
- Known hypersensitivity to Actovegin or similar compounds
- Pulmonary edema, anuria, oliguria, decompensated heart failure
- Electrolyte disturbances: hypernatremia, hyperchloremia
Use During Pregnancy & Lactation
Use only under medical supervision if benefits outweigh potential risks. No significant negative outcomes were observed in clinical data involving pregnant women.
Dosage and Administration
- IV/IM: 5–25 mL daily depending on severity
- Stroke: 20–50 mL IV + 250 mL saline/glucose daily, followed by lower dose
- DPN: 50 mL IV daily for 3 weeks, then oral tablets for 4–5 months
- Radiation injuries: 5–10 mL IV during radiotherapy course
- Intramuscular: No more than 5 mL per injection, administered slowly
Topical Application Instructions
Apply gel for wound cleaning; cream for intermediate healing; ointment for epithelialization.
Use appropriate dressings for burns and ulcers. Frequency depends on wound severity.
Overdose & Side Effects
Overdose data is limited. Treat symptoms if suspected. Possible allergic reactions include rash, urticaria, or rare anaphylaxis. Gastrointestinal upset may occur with oral/topical ingestion.
Storage Conditions
- Injectables: Store at 18–25°C. Do not reuse opened ampoules.
- Tablets & Topicals: Store below 25°C. Protect from light and humidity.
- Keep out of reach of children.