Actovegin Specialized Store

[tablets and injections]

Actovegin 200 mg, (50 tablets)

Actovegin tablets 200 mg.
Actovegin 200 mg. 50 tablets

$68.00

Actovegin tablets are used as a part of the complex therapy of metabolic and vascular disorders of the brain

  • various forms of cerebrovascular insufficiency, (dementia, traumatic brain injury);
  • peripheral (arterial and venous)
  • vascular disorders and their consequences (angiopathy, trophic ulcers).
Category:

Description

ACTOVEGIN® 200 mg – Coated Tablets

INN: Actovegin

Therapeutic Category: Antihypoxant, tissue regeneration stimulator

Form: Coated tablets, oral

Dosage: 200 mg deproteinized hemoderivative of calf blood per tablet (≈ 345 mg dry matter)

Packing: 50 coated tablets in tamper-evident dark-glass bottle with patient leaflet in carton

Manufacturer: Takeda Pharmaceuticals International AG (Japan/Austria)

Composition

  • Active: deproteinized calf blood hemoderivative – 200 mg (≈ 345 mg dry matter)
  • Excipients: magnesium stearate, talc, gum acacia, glycolic mineral wax, hypromellose phthalate, diethyl phthalate, aluminum lake yellow dye, macrogol-6000, povidone‑K30, sucrose, titanium dioxide, microcrystalline cellulose

Description

Bright greenish‑yellow round biconvex tablets with glossy coating, uniform finish and absence of visual defects.

Pharmacology & Mechanism

Actovegin is a highly purified ultrafiltrate of calf blood. It enhances cellular oxygen and glucose uptake, promoting ATP synthesis under hypoxic conditions. It also modulates NF‑κB signaling, inhibits PARP activity, and reduces apoptosis. Vascular effects include vasodilation via nitric oxide synthase, reduced arteriolar tone, and improved red blood cell deformability.

Onset of action: ~30 minutes. Peak effect: 2–6 hours after oral administration.

Indications

  • Post-stroke cognitive impairment (PSCI) and vascular dementia
  • Peripheral arterial or venous circulatory disorders and trophic complications
  • Diabetic peripheral neuropathy (DPN)

Contraindications

  • Hypersensitivity to components
  • Fructose intolerance, glucose-galactose malabsorption, sucrase-isomaltase deficiency
  • Children under 18 years

Use in sports:

Actovegin is widely used among athletes for its metabolic-enhancing and antihypoxic properties. Clinical data indicate that Actovegin improves oxygen uptake and glucose utilization at the cellular level, especially in skeletal muscles and the brain. This makes it potentially valuable during intense physical exertion or in hypoxic conditions. Athletes report faster recovery times, reduced muscle fatigue, and improved endurance, particularly during periods of high-intensity training or competition.

Moreover, Actovegin may support microcirculation and capillary perfusion, which enhances nutrient delivery and waste removal in working muscles. Some studies suggest it can accelerate muscle repair and tissue regeneration, making it useful in injury recovery protocols. While the drug is not classified as a performance enhancer by WADA, its use is often viewed as part of legal recovery and optimization strategies in high-performance sports.

Use During Pregnancy & Lactation

Limited data. Use only if potential benefit justifies potential risk to fetus or infant.

Dosage & Administration

Swallow whole before meals with water.

  • PSCI: IV 2000 mg/day (≤ 20 infusions), then oral 3×2 tablets/day (1200 mg/day) for 6 months
  • Dementia: Oral 3×2 tablets/day for 20 weeks
  • Circulatory disorders: 1–2 tablets, 3×/day, for 4–6 weeks
  • DPN: IV 2000 mg/day × 20 infusions, then oral 3×3 tablets/day (1800 mg/day) for 4–5 months

Adverse Effects & Overdose

Rare: rash, urticaria, flushing. Extremely rare: angioedema, anaphylaxis. No evidence of toxicity even at 30–40× standard doses. Treat symptomatically.

Drug Interactions

No significant interactions documented. Assess co-medication case-by-case.

Clinical Evidence

Patient Guidance

  • Complete full course unless directed otherwise
  • Monitor blood pressure, especially if used IV
  • Report signs of allergy immediately
  • Discuss all current medications with your provider
  • Not banned in sports, but check with governing bodies

Storage & Shelf Life

Store ≤ 25 °C, protect from moisture and light. Do not reuse opened ampoules. Shelf life: 3 years. Keep out of reach of children.

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